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DTSTAMP:20250905T080908Z
DESCRIPTION: \n\nThe Killam Seminar Series presents Aging and inflammation 
 as causes for remyelination failure and disease progression in MS.\n\nRegi
 stration (virtual) available here.\n\nLink to view virtually. If you would
  like to send in a question for the speaker\, fill in this form.\n\nTo att
 end in person\, register here\n\nSpeaker: Tanja Kuhlmann\, PhD\n\nProfesso
 r\, Neuropathology\, Institute of Neuropathology\, University Hospital Mün
 ster\, Germany\n\nAbstract: Multiple sclerosis (MS) is the most frequent d
 emyelinating disease in the central nervous system. MS disease courses pre
 sent a variable combination of relapse driven disease activity and disease
  progression independent of relapses resulting in disability accumulation.
  Although the relapse driven disease activity is highly amenable to therap
 eutic interventions\, disease progression still cannot be prevented. Remye
 lination\, the formation of new myelin sheaths after a demyelinating event
 \, is an endogenous repair process and promotion of remyelination represen
 ts a promising new treatment approach to stop disease progression. In my p
 resentation I discuss how inflammation and aging impairs oligodendroglial 
 functions and remyelination and how these factors contribute to disease pr
 ogression in MS.\n\nBio: Dr. Tanja Kuhlmann studied medicine at the Univer
 sity of Göttingen\, Germany where she received her medical degree in 1998.
  She specialized in neuropathology and worked as medical resident and rese
 arch fellow in different neuropathological departments in Germany and at M
 cGill\, Canada in the research groups of Dr. Jack Antel and Dr. Alan Peter
 son. In 2008\, she became senior consultant and associate professor\, Inst
 itute of Neuropatholohgy at the University Hospital Münster\, Germany and 
 in 2020 part-time adjunct professor\, Department of Neurology and Neurosur
 gery\, ÂÌñÉç. Her key research interests are mechanisms leadin
 g to axonal and oligodendroglial pathology in demyelinating diseases. In r
 ecent years\, she focused her research on iPSC technology and the derivati
 on of human CNS cells from iPSC to study disease mechanisms. She has publi
 shed several publications in well-known international journals on the topi
 c of MS pathology\, especially on oligodendroglial loss and remyelination 
 as well as studies using iPSC-derived oligodendrocytes and neurons to unde
 rstand disease mechanisms in demyelinating and neurodegenerative diseases.
 \n\n\nSupported by the generosity of the Killam Trusts \, The Neuro’s Kill
 am Seminar series hosts outstanding guest speakers.\n
DTSTART:20220329T200000Z
DTEND:20220329T210000Z
LOCATION:Jeanne Timmins Amphitheatre\, Montreal Neurological Institute\, CA
 \, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Aging and inflammation as causes for remyeli
 nation failure and disease progression in MS
URL:/neuro/channels/event/killam-seminar-series-aging-
 and-inflammation-causes-remyelination-failure-and-disease-progression-ms-3
 38536
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