BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250904T132602EDT-5059acLGbO@132.216.98.100 DTSTAMP:20250904T172602Z DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro' s Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at The Neuro and ÂÌñÉç Univers ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Edward Rut hazer\n\n\nHow form and function of neural circuits is shaped by oligodend rocyte precursor cells\n\nTim Czopka\n\nProfessor of Glial Cell Biology\, The University of Edinburgh\, United Kingdom\n\nAbstract: Glial cells comp rise up to 50% of all cells in the vertebrate central nervous system (CNS) and play crucial roles in regulating neural circuit connectivity through modulation of synapse formation and remodelling. Recently\, we have attrib uted this function to a glial cell type called the oligodendrocyte precurs or cell (OPC). OPCs have established roles in giving rise to myelinating o ligodendrocytes. However\, not all OPCs form myelin but they instead resid e in an undifferentiated state where they evenly distribute across the CNS \, thereby tiling the tissue by forming elaborate process networks. In thi s seminar\, I will present our investigations in the zebrafish visual syst em revealing that one of the myelination-independent functions of OPCs is fine tune axon and synapse remodelling crucial for developing visual acuit y. I will discuss some of our unpublished projects to elucidate mechanisms by which OPCs tune visual circuitry\, and conclude by discussing how dysf unctional OPCs may contribute to disorders of the developing CNS.\n\nDr. T im Czopka studied Biology and obtained his PhD in Neuroscience in 2009 fro m the Ruhr-University Bochum (Germany). Following his postdoctoral researc h at the University of Edinburgh (UK)\, he became a Principal Investigator in 2015 at the Technical University of Munich (Germany). In 2020\, he mov ed back to the University of Edinburgh\, where he has been a Professor of Glial Cell Biology since 2023.\n\nHis research group investigates the dive rsity and functions of oligodendrocytes to regulate the formation\, functi on\, and dysfunction of neuronal circuits. They use young zebrafish for th eir research\, as this model organism allows the study of genetics\, cellu lar dynamics\, and physiology at unprecedented resolution in an intact liv ing animal.\n DTSTART:20251007T200000Z DTEND:20251007T210000Z LOCATION:de Grandpre Communications Centre\, The Neuro SUMMARY:Killam Seminar Series: How form and function of neural circuits is shaped by oligodendrocyte precursor cells URL:/neuro/channels/event/killam-seminar-series-how-fo rm-and-function-neural-circuits-shaped-oligodendrocyte-precursor-cells-366 297 END:VEVENT END:VCALENDAR