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UID:20250909T183210EDT-1543Pz4IvL@132.216.98.100
DTSTAMP:20250909T223210Z
DESCRIPTION:Immune cells and their derived molecules have major impact on b
 rain function. Mice deficient in adaptive immunity have impaired cognitive
  and social function compared to that of wild-type mice. Importantly\, rep
 lenishment of the T cell compartment in immune deficient mice restored pro
 per brain function. We have identified several key T cell-derived cytokine
 s that mediate the effect. Despite the robust influence on brain function\
 , T cells are not found within the brain parenchyma\, a fact that only add
 s more mystery into these enigmatic interactions between T cells and the b
 rain. Our results suggest that meningeal space\, surrounding the brain\, i
 s the site where CNS-associated immune activity takes place. We have recen
 tly discovered a presence of meningeal lymphatic vessels that drain CNS mo
 lecules and immune cells to the deep cervical lymph nodes and also regulat
 e perfusion of the brain by CSF (glymphatic flow). This communication betw
 een the CNS and meninges is playing a key role in several neurological and
  psychiatric disorders and\, therefore\, may serve as a novel therapeutic 
 target that is worth in-depth mechanistic exploration.\n\nThe seminar will
  be given online via Zoom. Details in attached poster.\n
DTSTART:20210219T160000Z
DTEND:20210219T170000Z
SUMMARY:Online Seminar - The role of meningeal lymphatics in ageing and neu
 roinflammatory disorders
URL:/physiology/channels/event/online-seminar-role-men
 ingeal-lymphatics-ageing-and-neuroinflammatory-disorders-326626
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